Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.
Publication year
2004Source
The Lancet (London), 364, 9435, (2004), pp. 703-5ISSN
Publication type
Article / Letter to editor
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Organization
Medical Microbiology
Ophthalmology
Journal title
The Lancet (London)
Volume
vol. 364
Issue
iss. 9435
Page start
p. 703
Page end
p. 5
Subject
UMCN 4.1: Microbial pathogenesis and host defenseAbstract
Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous.
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- Academic publications [238426]
- Faculty of Medical Sciences [90358]
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