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| Title: | Nelfinavir plasma concentrations are low during pregnancy. |
| Author(s): | Nellen, J.F.
Schillevoort, I.
Wit, F.W.
Bergshoeff, A.S. (263438953)
Godfried, M.H.
Boer, K.
Lange, J.M.A.
Burger, D.M. (119962306)
Prins, J.M. |
| Publication year: | 2004 |
| Document type: | Article / Letter to editor |
| Journal: | Clinical Infectious Diseases |
| ISSN: | 1058-4838 |
| Volume: | vol. 39 |
| Issue: | iss. 5 |
| Start page: | p. 736 |
| End page: | p. 740 |
| Abstract: | Plasma nelfinavir concentration ratios (CRs) were calculated for all pregnant (n=27) and nonpregnant (n=48) human immunodeficiency virus type 1-infected women receiving the drug who visited our outpatient clinic. In pregnant women, mean and median nelfinavir CRs were significantly lower (P=.02 and P=.04, respectively), and 51% of the CRs were below the clinically relevant threshold of 0.90, compared with 35% of the CRs in nonpregnant women. After we adjusted for confounders, we found that the mean nelfinavir CR was 34% lower in pregnant women (P=.02). With targeted interventions, subsequent CRs in pregnant women showed a significant increase (median increase, 0.31; P=.01). |
| Subject: | UMCN 4.1: Microbial pathogenesis and host defense |
| Organization: | UMCN Extern
Clinical Pharmacy |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/58746
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