Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.

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Title:	Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.
Author(s):	Graaf, K.F.J. van de (314446508) Boullart, I. (314664777) Hoenderop, J.G.J. (195017544) Bindels, R.J.M. (07205378X)
Publication year:	2004
Document type:	Article / Letter to editor
Journal:	Journal of Steroid Biochemistry and Molecular Biology
ISSN:	0960-0760
Volume:	vol. 89-90
Issue:	iss. 1-5
Start page:	p. 303
End page:	p. 308
Abstract:	Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed.
Subject:	UMCN 5.4: Renal disorders
Organization:	Cell Physiology Tumorimmunology Physiology
Appears in Collections:	Academic bibliography

Please use this identifier to cite or link to this item: http://hdl.handle.net/2066/57722