Isolated limb infusion with fotemustine after dacarbazine chemosensitisation for inoperable loco-regional melanoma recurrence.
Fulltext:
57654.pdf
Embargo:
until further notice
Size:
102.5Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2004Source
European Journal of Surgical Oncology, 30, 10, (2004), pp. 1107-12ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Surgery
Journal title
European Journal of Surgical Oncology
Volume
vol. 30
Issue
iss. 10
Page start
p. 1107
Page end
p. 12
Subject
UMCN 1.5: Interventional oncologyAbstract
BACKGROUND: Isolated limb infusion (ILI) is a simple yet effective alternative to conventional isolated limb perfusion for the treatment of advanced melanoma of the extremities. PATIENTS AND METHODS: The study group comprised 13 patients with very advanced limb disease who had failed to achieve a satisfactory response to one or more ILIs with melphalan, and in whom amputation was the only other realistic treatment option. The aim of this study was to evaluate the efficacy and toxicity of ILI with fotemustine after systemic chemosensitisation with dacarbazine (DTIC). RESULTS: Complete remission was achieved in four patients and partial remission in eight patients, with a median response duration of 3 months. Limb salvage was achieved in five of 12 assessable patients (42%). Limb toxicity peaked 9 days after ILI; two patients experienced Wieberdink grade IV (severe) toxicity and four patients had grade V toxicity (requiring early amputation). CONCLUSIONS: ILI with fotemustine after DTIC chemosensitisation can be successful when gross limb disease has not been controlled by one or more ILIs with melphalan. However, it cannot be recommended as a routine method of treatment for advanced melanoma of the extremities because of the high incidence of severe limb toxicity.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122536]
- Faculty of Medical Sciences [90373]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.