More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon.
Fulltext:
57393.pdf
Embargo:
until further notice
Size:
601.7Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2004Source
American Journal of Surgical Pathology, 28, 6, (2004), pp. 706-11ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Gynaecology
Health Evidence
Human Genetics
Pathology
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
American Journal of Surgical Pathology
Volume
vol. 28
Issue
iss. 6
Page start
p. 706
Page end
p. 11
Subject
EBP 1: Determinants in Health and Disease; UMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 1.3: Tumor microenvironment; UMCN 1.5: Interventional oncology; UMCN 5.4: Renal disordersAbstract
PURPOSE: Recognition of hereditary nonpolyposis colorectal cancer (HNPCC)-related endometrial carcinoma from sporadic carcinoma by histologic features as compared with colonic cases. STUDY DESIGN: Case-control study. METHODS AND MATERIALS: From the files of the Nijmegen Hereditary Cancer Clinic, HNPCC-related (n = 6) endometrial and colorectal (n = 18) carcinomas were selected. For every HNPCC-related tumor, 2 sporadic control cases were included. The tumors were evaluated for the following 7 pathologic features: tumor differentiation, T-stage, growth pattern, presence of Crohn-like lymphoid reaction, mucinous differentiation, presence of lymphangioinvasive growth, and the amount of tumor-infiltrating lymphocytes. RESULTS: HNPCC-related endometrial carcinomas were significantly more often poorly differentiated (83% versus 27%), more often showed the presence of a Crohn-like lymphoid reaction (100% versus 13%) and lymphangioinvasive growth (67% versus 0%), and high number of tumor-infiltrating lymphocytes were more often present (100% versus 36%) compared with sporadic endometrial carcinomas. The differences between HNPCC and sporadic colorectal cancer specimens were less discriminating. CONCLUSIONS: HNPCC-related endometrial carcinomas are characterized by poor differentiation, more frequent Crohn-like lymphoid reaction, lymphangioinvasive growth and more tumor-infiltrating lymphocytes. These features therefore might form the basis for selecting patients for counseling in a hereditary cancer clinic or testing for microsatellite instability or mutation analysis of mismatch repair genes, especially when they are of relatively young age.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122536]
- Faculty of Medical Sciences [90373]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.