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Publication year
2004Source
Physiological Genomics, 19, 1, (2004), pp. 50-60ISSN
Publication type
Article / Letter to editor
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Organization
Cell Biology (UMC)
Tumorimmunology
Journal title
Physiological Genomics
Volume
vol. 19
Issue
iss. 1
Page start
p. 50
Page end
p. 60
Subject
UMCN 1.4: Immunotherapy, gene therapy and transplantation; UMCN 5.3: Cellular energy metabolismAbstract
Mouse PTP-BL is a large, nontransmembrane protein tyrosine phosphatase of unclear physiological function that consists of a KIND domain, a FERM domain, five PDZ domains, and a COOH-terminal catalytic PTP domain. PTP-BL and its human ortholog PTP-BAS have been proposed to play a role in the regulation of microfilament dynamics, cytokinesis, apoptosis, and neurite outgrowth. To investigate the biological function of PTP-BL enzyme activity, we have generated mice that lack the PTP-BL PTP moiety. These PTP-BL(DeltaP/DeltaP) mice are viable and fertile and do not present overt morphological alterations. Although PTP-BL is expressed in most hematopoietic cell lineages, no alterations of thymocyte development in PTP-BL(DeltaP/DeltaP) mice could be detected. Sciatic nerve lesioning revealed that sensory nerve recovery is unaltered in these mice. In contrast, a very mild but significant impairment of motor nerve repair was observed. Our findings exclude an essential role for PTP-BL as a phosphotyrosine phosphatase and rather are in line with a role as scaffolding or anchoring molecule.
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- Electronic publications [122508]
- Faculty of Medical Sciences [90358]
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