Pneumolysin is a key factor in misidentification of macrolide-resistant Streptococcus pneumoniae and is a putative virulence factor of S. mitis and other streptococci.
Publication year
2004Source
Journal of Clinical Microbiology, 42, 9, (2004), pp. 4355-7ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Intensive Care
Biochemistry (UMC)
Medical Microbiology
Journal title
Journal of Clinical Microbiology
Volume
vol. 42
Issue
iss. 9
Page start
p. 4355
Page end
p. 7
Subject
UMCN 4.1: Microbial pathogenesis and host defenseAbstract
We evaluated the applicability of ply PCR for confirmation of the identification of Streptococcus pneumoniae. lytA PCR, 16S rRNA sequencing, and amplified-fragment length polymorphism were used as reference methods. In contrast to the lytA gene, the ply gene proved to be not specific for S. pneumoniae. The presence of the ply gene in other streptococci, in particular Streptococcus mitis, suggests that pneumolysin plays a pathogenic role.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.