The effects of vigabatrin on spike and wave discharges in WAG-Rij rats

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Title:	The effects of vigabatrin on spike and wave discharges in WAG-Rij rats
Author(s):	Bouwman, B.M. (29134917X) Suffczynski, P. Midzyanovskaya, I.S. (297644106) Maris, E. (184925568) Broek, P.L.C. van den (243985630) Rijn, C.M. van (074256122)
Publication year:	2007
Document type:	Article / Letter to editor
Journal:	Epilepsy Research
ISSN:	0920-1211
Volume:	vol. 76
Issue:	iss. 1
Start page:	p. 34
End page:	p. 40
Abstract:	The effects of vigabatrin, which increases GABA concentrations by inhibiting GABA transaminase, on spike and wave discharges (SWDs) in the electroencephalogram of WAG/Rij rats were studied. Vigabatrin increased the incidence and duration of the SWDs, suggesting a quantitative GABA(A)ergic involvement in the mechanism(s) underlying the starting and stopping of an ongoing SWD. Also, vigabatrin decreased the SWD peak frequency, suggesting an important role of GABA(B) in the mechanism(s) underlying the peak frequency of the SWDs. Vigabatrin gradually changed the course of the hazard rates of the SWD durations, suggesting a quatitative GABAergic role in the mechanism(s) underlying the stopping of an ongoing SWD.
Subject:	Cognitive neuroscience
Organization:	SW OZ DCC BI FSW_Fac. algemeen F.C. Donders Centre for Cognitive Neuroimaging SW OZ DCC KI
Organization (former):	SW OZ NICI BI SW OZ NICI KI
Appears in Collections:	Academic bibliography

Please use this identifier to cite or link to this item: http://hdl.handle.net/2066/56060