Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study.
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Publication year
2007Source
Cancer Letters, 250, 1, (2007), pp. 146-53ISSN
Publication type
Article / Letter to editor
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Organization
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Cancer Letters
Volume
vol. 250
Issue
iss. 1
Page start
p. 146
Page end
p. 53
Subject
From Natural Philosophy to Science; NCEBP 1: Molecular epidemiology; ONCOL 1: Hereditary cancer and cancer-related syndromes; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; UMCN 1.5: Interventional oncologyAbstract
Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.
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- Academic publications [238441]
- Electronic publications [122544]
- Faculty of Medical Sciences [90373]
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