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| Title: | Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 |
| Author(s): | Pel, H.J.
Winde, J.H. de
Archer, D.B.
Dyer, P.S.
Hofmann, G.
Schaap, P.J.
Turner, G.
Vries, R.P. de
Albang, R.
Albermann, K.
Andersen, M.R.
Bendtsen, J.D.
Benen, J.A.
Berg, M. van den
Breestraat, S.
Caddick, M.X.
Contreras, R.
Cornell, M.
Coutinho, P.M.
Danchin, E.G.
Debets, A.J.
Dekker, P.
Dijck, P.W. van
Dijk, A. van (298207257)
Dijkhuizen, L.
Driessen, A.J.
Enfert, C. d'
Geysens, S.
Goosen, C.
Groot, G.S.
Groot, P.W. de
Guillemette, T.
Henrissat, B.
Herweijer, M.
Hombergh, J.P. van den
Hondel, C.A. van den
Heijden, R.T.J.M. van der
Kaaij, R.M. van der
Klis, F.M.
Kools, H.J.
Kubicek, C.P.
Kuyk, P.A. van
Lauber, J.
Lu, X.
Maarel, M.J. van der
Meulenberg, R.
Menke, H.
Mortimer, M.A.
Nielsen, J.
Oliver, S.G.
Olsthoorn, M.
Pal, K.
Peij, N.N. van
Ram, A.F.
Rinas, U.
Roubos, J.A.
Sagt, C.M.
Schmoll, M.
Sun, J.
Ussery, D.
Varga, J.
Vervecken, W.
Vondervoort, P.J. van de
Wedler, H.
Wosten, H.A.
Zeng, A.P.
Ooyen, A.J. van
Visser, J. (298206404)
Stam, H. |
| Publication year: | 2007 |
| Document type: | Article / Letter to editor |
| Journal: | Nature Biotechnology |
| ISSN: | 1087-0156 |
| Volume: | vol. 25 |
| Issue: | iss. 2 |
| Start page: | p. 221 |
| End page: | p. 231 |
| Annotation: | Journal Article Research Support, Non-U.S. Gov't |
| Abstract: | The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis. |
| Subject: | Bioinformatics
UMCN 5.3: Cellular energy metabolism |
| Organization: | UMCN Extern
Gastroenterology
FSW_Fac. algemeen
NCMLS 3a
CMBI
Psychiatry |
| Organization (former): | Bioinformatics (umcn)
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| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/51722
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