Publication year
2007Source
Journal of Neuroimmunology, 190, 1-2, (2007), pp. 127-30ISSN
Publication type
Article / Letter to editor
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Organization
Paediatrics - OUD tm 2017
Journal title
Journal of Neuroimmunology
Volume
vol. 190
Issue
iss. 1-2
Page start
p. 127
Page end
p. 30
Subject
N4i 1: Pathogenesis and modulation of inflammation; NCMLS 1: Infection and autoimmunity; UMCN 4.1: Microbial pathogenesis and host defenseAbstract
Macrophages infiltrate peripheral nerves and may contribute to neural damage in the Guillain-Barre syndrome (GBS). We determined whether single nucleotide polymorphisms (SNP) in genes encoding macrophage-mediators are related to the susceptibility and severity of GBS. The frequencies of SNP in the TNFA, MMP9, IL10, and NOS2a genes did not differ between 263 GBS patients and 210 healthy subjects. The MMP9 C(-1562)T and TNFA C(-863)A SNP were associated with severe weakness and poor outcome, indicating that these SNP may be one of the factors predisposing to a severe form of GBS.
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- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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