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| Title: | Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved? |
| Author(s): | Bavel, C.C.A.W. van (298982692)
Vlag, J. van der (125696957)
Berden, J.H.M. (068420005) |
| Publication year: | 2007 |
| Document type: | Article / Letter to editor |
| Journal: | Kidney International |
| ISSN: | 0085-2538 |
| Volume: | vol. 71 |
| Issue: | iss. 7 |
| Start page: | p. 600 |
| End page: | p. 601 |
| Abstract: | The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures. |
| Subject: | UMCN 5.4: Renal disorders |
| Organization: | Nephrology |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/51697
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