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| Title: | The genotypic inhibitory quotient and the (cumulative) number of mutations predict the response to lopinavir therapy. |
| Author(s): | Hoefnagel, J.G.
Lee, M.J. van der (298983206)
Koopmans, P.P. (069689032)
Schuurman, R.
Jurriaans, S.
Sighem, A.I. van
Gras, L.
Wolf, F. de
Galama, J.M.D. (067845878)
Burger, D.M. (119962306) |
| Publication year: | 2006 |
| Document type: | Article / Letter to editor |
| Journal: | AIDS |
| ISSN: | 0269-9370 |
| Volume: | vol. 20 |
| Issue: | iss. 7 |
| Start page: | p. 1069 |
| End page: | p. 1071 |
| Abstract: | For 95 protease inhibitor-experienced HIV-1-infected patients, the genotypic inhibitory quotient (GIQ; trough level/number of mutations) was calculated for lopinavir. Three different sets of mutations showed equal predictive value. However, the use of cumulative numbers of mutations for calculation of the GIQ showed significantly better association with the virological response. Furthermore, the predictive value of the GIQ was no different from that of the number of mutations alone. |
| Subject: | CTR 2: Clinical Pharmacology and physiology
EBP 3: Effective Primary Care and Public Health
NCMLS 1: Immunity, infection and tissue repair
UMCN 3.2: Cognitive neurosciences
UMCN 4.1: Microbial pathogenesis and host defense |
| Organization: | UMCN Extern
Clinical Pharmacy
General Internal Medicine
Medical Microbiology |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/51011
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