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| Title: | Interleukin-8 CSF levels predict survival in patients with leptomeningeal metastases. |
| Author(s): | Brandsma, D.
Taphoorn, M.J.B.
Jager, W. de
Bonfrer, H.
Algra, A.
Reijneveld, J.C.
Boogerd, W.
Korse, T.
Verbeek, M.M. (15230147X)
Rijkers, G.T.
Voest, E.E. (108595420) |
| Publication year: | 2006 |
| Document type: | Article / Letter to editor |
| Journal: | Neurology |
| ISSN: | 0028-3878 |
| Volume: | vol. 66 |
| Issue: | iss. 2 |
| Start page: | p. 243 |
| End page: | p. 246 |
| Abstract: | Median survival of patients with leptomeningeal metastases (LM) is 4 to 6 months, with a few long-term survivors. Current prognostic factors for survival have limited value. The authors measured the CSF levels of nine inflammatory proteins in 57 patients with LM and determined their prognostic value. High interleukin (IL)-8 CSF levels predicted short-term survival independently. The data indicate that IL-8 CSF levels may serve as a prognosticator in patients with LM, but prospective validation is needed. |
| Subject: | UMCN 3.2: Cognitive neurosciences
UMCN 5.1: Genetic defects of metabolism |
| Organization: | UMCN Extern
Neurology
Tumorimmunology |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/50834
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