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| Title: | Regulation of TRPV5 and TRPV6 by associated proteins |
| Author(s): | Graaf, S.F.J. van de (285608061)
Hoenderop, J.G.J. (195017544)
Bindels, R.J.M. (07205378X) |
| Publication year: | 2006 |
| Document type: | Article / Letter to editor |
| Journal: | American Journal of Physiology : Renal Physiology |
| ISSN: | 0363-6127 |
| Volume: | vol. 290 |
| Issue: | iss. 6 |
| Start page: | p. F1295 |
| End page: | p. 302 |
| Abstract: | The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes. |
| Subject: | UMCN 5.4: Renal disorders |
| Organization: | Physiology |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/50484
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