Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications.

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Title:	Pharmacokinetics of once-daily lopinavir/ritonavir and the influence of dose modifications.
Author(s):	Porte, C.J.L. la (274142724) Schippers, E.F. Ende, M.E. van der Koopmans, P.P. (069689032) Blok, W.L. Kauffmann, R.H. Kroon, F.P. Burger, D.M. (119962306)
Publication year:	2005
Document type:	Article / Letter to editor
Journal:	AIDS
ISSN:	0269-9370
Volume:	vol. 19
Issue:	iss. 10
Start page:	p. 1105
End page:	p. 1107
Abstract:	We studied the pharmacokinetics of lopinavir/ritonavir dosed at 800/200 mg a day in 20 HIV-1-infected patients, and evaluated the effect of dose modifications in the case of trough concentration (Ctrough) levels less than 1.0 mg/l. Ctrough levels after the daily administration of lopinavir/ritonavir were lower than with twice daily administration. Dose modifications in four patients with Ctrough levels less than 1.0 mg/l succeeded in only one patient. Therapeutic drug monitoring can identify patients with lower-than-expected lopinavir exposure in a larger study.
Subject:	EBP 3: Effective Primary Care and Public Health UMCN 3.2: Cognitive neurosciences UMCN 4.1: Microbial pathogenesis and host defense
Organization:	Clinical Pharmacy UMCN Extern General Internal Medicine
Appears in Collections:	Academic bibliography

Please use this identifier to cite or link to this item: http://hdl.handle.net/2066/49125