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| Title: | The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease. |
| Author(s): | Abel, M. van
Hoenderop, J.G.J. (195017544)
Bindels, R.J.M. (07205378X) |
| Publication year: | 2005 |
| Document type: | Article / Letter to editor |
| Journal: | Naunyn-Schmiedebergs Archives of Pharmacology |
| ISSN: | 0028-1298 |
| Volume: | vol. 371 |
| Issue: | iss. 4 |
| Start page: | p. 295 |
| End page: | p. 306 |
| Abstract: | The epithelial Ca(2+) channels TRPV5 and TRPV6 represent a new family of Ca(2+) channels that belongs to the superfamily of transient receptor potential channels. TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) transport in kidney and intestine. The central role of TRPV5 and TRPV6 in active Ca(2+) (re)absorption makes it a prime target for regulation to maintain Ca(2+) balance. This review covers the hormonal regulation, interaction with accessory proteins and (patho)physiological implications of these epithelial Ca(2+) channels. |
| Subject: | UMCN 5.4: Renal disorders |
| Organization: | Physiology |
| Appears in Collections: | Academic bibliography
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/48377
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