|
DSpace at RU >
University Library >
Academic bibliography >
Files in This Item:
| File |
Description |
Size | Format |
|---|
 | publisher's version | 347.79 kB | Adobe PDF | Under Embargo
|
|
| Title: | The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. |
| Author(s): | Chang, Q. (298978962)
Hoefs, S.J.G. (298977427)
Kemp, J.W.C.M. van der (298976277)
Topala, C.N. (313052646)
Bindels, R.J.M. (07205378X)
Hoenderop, J.G.J. (195017544) |
| Publication year: | 2005 |
| Document type: | Article / Letter to editor |
| Journal: | Science |
| ISSN: | 0036-8075 |
| Volume: | vol. 310 |
| Issue: | iss. 5747 |
| Start page: | p. 490 |
| End page: | p. 493 |
| Abstract: | Blood calcium concentration is maintained within a narrow range despite large variations in dietary input and body demand. The Transient Receptor Potential ion channel TRPV5 has been implicated in this process. We report here that TRPV5 is stimulated by the mammalian hormone klotho. Klotho, a beta-glucuronidase, hydrolyzes extracellular sugar residues on TRPV5, entrapping the channel in the plasma membrane. This maintains durable calcium channel activity and membrane calcium permeability in kidney. Thus, klotho activates a cell surface channel by hydrolysis of its extracellular N-linked oligosaccharides. |
| Subject: | UMCN 5.4: Renal disorders |
| Organization: | Physiology |
| Appears in Collections: | Academic bibliography
|
|
Please use this identifier to cite or link to this item:
http://hdl.handle.net/2066/48195
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|
|
