Sensitivity-enhanced 13C MR spectroscopy of the human brain at 3 Tesla.
Publication year
2006Source
Magnetic Resonance in Medicine, 55, 2, (2006), pp. 271-8ISSN
Publication type
Article / Letter to editor
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Organization
Radiology
Internal Medicine
Solid State NMR
Former Organization
Physical Chemistry/Solid State NMR
Journal title
Magnetic Resonance in Medicine
Volume
vol. 55
Issue
iss. 2
Page start
p. 271
Page end
p. 8
Subject
IGMD 5: Health aging / healthy living; IGMD 8: Mitochondrial medicine; NCMLS 4: Energy and redox metabolism; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection; Solid State NMR; UMCN 1.1: Functional Imaging; UMCN 2.2: Vascular medicine and diabetesAbstract
A new coil design for sensitivity-enhanced 13C MR spectroscopy (MRS) of the human brain is presented. The design includes a quadrature transmit/receive head coil optimized for 13C MR sensitivity. Loss-less blocking circuits inside the coil conductors allow this coil to be used inside a homogeneous circularly polarized 1H B1 field for 1H decoupled 13C MRS. A quadrature 1H birdcage coil optimized for minimal local RF heating makes broadband 1H decoupling in the entire human brain possible at 3 Tesla while remaining well within international safety guidelines for RF absorption. Apart from a substantial increase in sensitivity compared to conventional small linear coils, the quadrature 13C coil combined with the quadrature 1H birdcage coil allows efficient cross polarization (CP) in the brain, resulting in an additional 3.5-fold sensitivity improvement compared to direct 13C measurements without nuclear Overhauser enhancement (NOE) or polarization transfer. Combined with the gain in power efficiency, this setup allows broadband 1H to 13C CP over large areas of the brain. Clear 13C resonances from glutamate (Glu), glutamine (Gln), aspartate (Asp), lactate (Lac), and gamma-aminobutyrate (GABA) carbon spins in the human brain demonstrate the quality of 13C MR spectra obtained in vivo with this coil setup.
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- Faculty of Medical Sciences [90373]
- Faculty of Science [34986]
- Open Access publications [97504]
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