System consolidation during sleep - a common principle underlying psychological and immunological memory formation
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Publication year
2015Source
Trends in Neurosciences, 38, 10, (2015), pp. 585-97ISSN
Publication type
Article / Letter to editor
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Organization
Tumorimmunology
Journal title
Trends in Neurosciences
Volume
vol. 38
Issue
iss. 10
Page start
p. 585
Page end
p. 97
Subject
Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life SciencesAbstract
Sleep benefits the consolidation of psychological memory, and there are hints that sleep likewise supports immunological memory formation. Comparing psychological and immunological domains, we make the case for active system consolidation that is similarly established in both domains and partly conveyed by the same sleep-associated processes. In the psychological domain, neuronal reactivation of declarative memory during slow-wave sleep (SWS) promotes the redistribution of representations initially stored in hippocampal circuitry to extra-hippocampal circuitry for long-term storage. In the immunological domain, SWS seems to favor the redistribution of antigenic memories initially held by antigen-presenting cells, to persisting T cells serving as a long-term store. Because storage capacities are limited in both systems, system consolidation presumably reduces information by abstracting 'gist' for long-term storage.
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- Faculty of Medical Sciences [90373]
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