Detection of verocytotoxin bound to circulating polymorphonuclear leukocytes of patients with hemolytic uremic syndrome.
Publication year
2001Source
Journal of the American Society of Nephrology, 12, 4, (2001), pp. 800--6ISSN
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Publication type
Article / Letter to editor
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Organization
Paediatrics - OUD tm 2017
Journal title
Journal of the American Society of Nephrology
Volume
vol. 12
Issue
iss. 4
Page start
p. 800-
Page end
p. 6
Subject
Inborn errors of metabolism; Disturbances in biochemical and functional development of the kidney during childhood.; Erfelijke stofwisselingsziekten; Stoornissen in de biochemische en functionele ontwikkeling van de nier op kinderleeftijdAbstract
The epidemic form of hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children and is characterized by a prodromal phase of sometimes bloody diarrhea. The role of verocytotoxin (VT)-producing Escherichia coli has been strongly implicated. Although antibodies against VT have been detected in the serum of patients with HUS, VT itself has never been detected in circulating blood. In this study, VT-2 was detected in the systemic circulation in 9 of 10 patients with the epidemic form of HUS. In those cases, VT-2 was bound exclusively to polymorphonuclear leukocytes (PMN). The detection of VT-2 bound to PMN was associated with the presence of diarrhea at the time the blood samples were obtained. The one patient for whom VT was not detected presented with atypical HUS. For 5 of the 10 patients with HUS who were studied, the time course of VT binding was analyzed; binding decreased in four patients. The finding of VT bound to PMN in the systemic circulation of patients with HUS is important for a clearer understanding of the pathogenesis of HUS and suggests new approaches for treatment in the future.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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