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Publication year
2004Source
The Lancet (London), 363, 9405, (2004), pp. 325-7ISSN
Publication type
Article / Letter to editor
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Organization
Medical Microbiology
Paediatrics - OUD tm 2017
Ecological Microbiology
Journal title
The Lancet (London)
Volume
vol. 363
Issue
iss. 9405
Page start
p. 325
Page end
p. 7
Subject
UMCN 1.4: Immunotherapy, gene therapy and transplantation; UMCN 4.1: Microbial pathogenesis and host defenseAbstract
A major difficulty with the detection of circulating galactomannan, a cell-wall polysaccharide released by Aspergillus sp during growth, in the serodiagnosis of invasive aspergillosis is the occurrence of false-positive ELISA results, especially in neonates and infants. On the basis of molecule similarity, we postulate that a lipoteichoic acid of Bifidobacterium sp can act as epitope for the monoclonal antibody used in the ELISA. The neonatal gut is heavily colonised with Bifidobacterium sp and these bacteria or their lipoteichoic acid might cause ELISA reactivity with serum after translocation because of immaturity of the intestinal mucosa. If our hypothesis is correct, we might find a method to discriminate between false-positive and true-positive ELISA results and thereby prevent unnecessary pre-emptive treatment of patients.
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- Academic publications [238441]
- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
- Faculty of Science [34986]
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