ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy
Publication year
2013Author(s)
Source
Plos Genetics, 9, 2, (2013), pp. e1003270ISSN
Publication type
Article / Letter to editor
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Organization
Neurology
Journal title
Plos Genetics
Volume
vol. 9
Issue
iss. 2
Page start
p. e1003270
Subject
DCN MP - Plasticity and memoryAbstract
Recent advances in the identification of susceptibility genes and environmental exposures provide broad support for a post-infectious autoimmune basis for narcolepsy/hypocretin (orexin) deficiency. We genotyped loci associated with other autoimmune and inflammatory diseases in 1,886 individuals with hypocretin-deficient narcolepsy and 10,421 controls, all of European ancestry, using a custom genotyping array (ImmunoChip). Three loci located outside the Human Leukocyte Antigen (HLA) region on chromosome 6 were significantly associated with disease risk. In addition to a strong signal in the T cell receptor alpha (TRA@), variants in two additional narcolepsy loci, Cathepsin H () and Tumor necrosis factor (ligand) superfamily member 4 (, also called ), attained genome-wide significance. These findings underline the importance of antigen presentation by HLA Class II to T cells in the pathophysiology of this autoimmune disease.
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- Academic publications [238441]
- Electronic publications [122508]
- Faculty of Medical Sciences [90373]
- Open Access publications [97504]
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