The efficacy of mindfulness-based cognitive therapy in recurrent depressed patients with and without a current depressive episode: a randomized controlled trial.
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Publication year
2012Source
Psychological Medicine, 42, 5, (2012), pp. 989-1001ISSN
Annotation
01 mei 2012
Publication type
Article / Letter to editor
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Organization
Psychiatry
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Psychological Medicine
Volume
vol. 42
Issue
iss. 5
Page start
p. 989
Page end
p. 1001
Subject
NCEBP 2: Evaluation of complex medical interventions; NCEBP 9: Mental healthAbstract
BACKGROUND: The aim of this study is to examine the efficacy of mindfulness-based cognitive therapy (MBCT) in addition to treatment as usual (TAU) for recurrent depressive patients with and without a current depressive episode. METHOD: A randomized, controlled trial comparing MBCT+TAU (n=102) with TAU alone (n=103). The study population consisted of patients with three or more previous depressive episodes. Primary outcome measure was post-treatment depressive symptoms according to the Hamilton Rating Scale for Depression. Secondary outcome measures included the Beck Depression Inventory, rumination, worry and mindfulness skills. Group comparisons were carried out with linear mixed modelling, controlling for intra-group correlations. Additional mediation analyses were performed. Comparisons were made between patients with and without a current depressive episode. RESULTS: Patients in the MBCT+TAU group reported less depressive symptoms, worry and rumination and increased levels of mindfulness skills compared with patients receiving TAU alone. MBCT resulted in a comparable reduction of depressive symptoms for patients with and without a current depressive episode. Additional analyses suggest that the reduction of depressive symptoms was mediated by decreased levels of rumination and worry. CONCLUSIONS: The study findings suggest that MBCT is as effective for patients with recurrent depression who are currently depressed as for patients who are in remission. Directions towards a better understanding of the mechanisms of action of MBCT are given, although future research is needed to support these hypotheses.
This item appears in the following Collection(s)
- Academic publications [238586]
- Electronic publications [122846]
- Faculty of Medical Sciences [90409]
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