Publication year
2012Source
International Journal of Sport Nutrition and Exercise Metabolism, 22, 2, (2012), pp. 79-88ISSN
Annotation
01 april 2012
Publication type
Article / Letter to editor
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Organization
Laboratory of Genetic, Endocrine and Metabolic Diseases
Journal title
International Journal of Sport Nutrition and Exercise Metabolism
Volume
vol. 22
Issue
iss. 2
Page start
p. 79
Page end
p. 88
Subject
IGMD 7: Iron metabolism N4i 1: Pathogenesis and modulation of inflammation; N4i 1 - pathogenesis and modulation of inflammation Oncol 5 - Aetiology, screening and detectionAbstract
PURPOSE: To investigate the effects of acute exercise on serum hepcidin and iron (sFe) in active women. Changes in interleukin-6 (IL-6), hepcidin, ferritin, and sFe in response to 2 different exercise durations were compared. METHODS: Twelve women age 19-32 yr performed 2 treadmill runs (60 and 120 min) at 65% of VO2max. Blood samples were obtained before, immediately after, and 3, 6, 9, and 24 hr after exercise. Two-way repeated-measures ANOVA was conducted to examine changes in measured variables. Significance was accepted at p < .05. RESULTS: Significant effects for trial were observed for hepcidin (60 min: 1.15 +/- 0.48 nmol/L; 120 min: 2.28 +/- 1.44 nmol/L) and for time, with hepcidin significantly increased 3 hr postexercise in both trials (60 min: 3 hr - 1.99 +/- 2.00 nmol/L; 120 min: 3 hr - 4.60 +/- 4.61 nmol/L). Significant main effects for time occurred for sFe, ferritin, and IL-6. sFe was significantly decreased 9 hr postexercise compared with 3 and 24 hr postexercise. IL-6 was significantly increased immediately postexercise. CONCLUSIONS: Both runs resulted in significant increases in hepcidin 3 hr after exercise. Increases in hepcidin were preceded by significant increases in IL-6 immediately postexercise and followed by significant decreases in sFe 9 hr postexercise. It was concluded that endurance exercise increases the production of hepcidin, which affects sFe. The 2-hr exercise bout stimulated greater changes in serum hepcidin than the 1-hr bout.
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- Academic publications [238586]
- Faculty of Medical Sciences [90409]
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